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We welcome collaborators, partners, and supporters as we develop the next generation of programmable genetic medicines.
The Logic Layer.
Cancer disables the systems that maintain genomic integrity. Small cell lung cancer is the best example of this: nearly all tumors block the pathways that normally halt division during stress. When these systems fail, cells continue dividing despite DNA damage accumulation.
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Architecture
We set out to rebuild this logic. Our architecture uses two coordinated components:
[1]
A sensor–effector fusion that connects stress signals to therapeutic action
[2]
A natural negative regulator that shuts the system down in healthy cells
In stable cells, the regulator keeps the entire program silent.
In unstable cells, chronic damage weakens suppression and activates the effector.
The result is a decision system that operates only where instability is sustained. It avoids promoter leakage, reduces off-target risk, and uses a signal cancer cannot easily silence—cellular stress.
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Our team is building a library of sensors, regulators, and effector modules that can be recombined into new architectures. Instead of single-gene therapies, we are creating a programmable system for diseased cells.